| Gene Information | |
|---|---|
| Gene Name | RYR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4967 |
| Protein Names | Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor) |
| Target Name | ryanodine receptor 2 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000198626 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | RYR2 |
| Uniprot ID | Q92736 |
| Pfam | PF08709; PF00520; PF02815; PF08454; PF06459; PF01365; PF02026; PF00622 |
| In ASD | yes |
| Allosteric Prediction | yes (1.507012164) |
| Ortholog in Animals | Alpaca_ RYR2 ( ortholog_one2one ) Dog_ RYR2 ( ortholog_one2one ) GuineaPig_ RYR2 ( ortholog_one2one ) Macaque_ RYR2 ( ortholog_one2one ) Mouse_ Ryr2 ( ortholog_one2one ) Pig_ RYR2 ( ortholog_one2one ) Rat_ Ryr2 ( ortholog_one2one ) Rabbit_ RYR2 ( ortholog_one2one ) |
| Ohnologs | RYR1, RYR3 |
| Paralogs | ITPR2, ITPR3, RYR1, ITPR1, RYR3 |
| Tissue | heart, atrium, left.ventricle |
| Tissue Specificity | Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:9607712}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4JKQ (X-ray 2.39A ) 6Y4O (X-ray 1.84A ) 6Y4P (X-ray 2.13A ) 7KL5 (X-ray 1.65A ) 7U9Q (EM 3.11A ) 7U9R (EM 3.69A ) 7U9T (EM 2.68A ) 7U9X (EM 2.58A ) 7U9Z (EM 3.29A ) 7UA1 (EM 2.99A ) 7UA3 (EM 2.97A ) 7UA4 (EM 2.93A ) 7UA5 (EM 2.83A ) 7UA9 (EM 3.59A ) |
| DBSNP | rs764772142 rs794728708 rs371121679 rs1349176732 rs190140598 rs121918602 rs376612295 rs16835270 rs3766871 rs121918597 rs794728746 rs794728747 rs121918603 rs121918601 rs794728753 rs772220753 rs1456929288 rs121918598 rs769219555 rs34967813 rs1472508624 rs1239093704 rs794728777 rs794728784 rs121918599 rs1385881911 rs1349585791 rs1202962809 rs1234963411 rs121918605 rs121918600 rs1457271141 rs1323621379 rs397516510 rs189345192 rs1359163728 rs121918604 rs1188352725 rs794728804 rs1363298408 rs121918606 rs1218096653 rs1242723821 rs1185619003 rs1475453069 rs886039172 rs1553343100 rs794728811 |
| Subcellular location [CC] | Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:10830164}; Multi-pass membrane protein {ECO:0000269|PubMed:10830164}. Membrane {ECO:0000305|PubMed:10830164}; Multi-pass membrane protein {ECO:0000305|PubMed:10830164}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P30957}. Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |