| Gene Information | |
|---|---|
| Gene Name | RYK |
| Organism | Homo sapiens (Human) |
| Gene Length | 607 |
| Protein Names | Tyrosine-protein kinase RYK (EC 2.7.10.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000163785 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P34925 |
| Gene Card | RYK |
| Uniprot ID | P34925 |
| Pfam | PF07714; PF02019 |
| In ASD | no |
| Allosteric Prediction | yes (0.040374481) |
| Ortholog in Animals | Alpaca_ RYK ( ortholog_one2one ) Dog_ RYK ( ortholog_one2one ) GuineaPig_ RYK ( ortholog_one2one ) Macaque_ RYK ( ortholog_one2one ) Mouse_ Ryk ( ortholog_one2one ) Pig_ RYK ( ortholog_one2one ) Rat_ Ryk ( ortholog_one2one ) Rabbit_ RYK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Observed in all the tissues examined. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6TUA (X-ray 2.38A ) |
| DBSNP | rs1131262 rs55740278 rs746238409 |
| Subcellular location [CC] | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |