Gene Information
Gene NameRYDR
OrganismHomo sapiens (Human)
Gene Length5038
Protein NamesRyanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBNA
Gene CardRYR1
Uniprot IDP21817
PfamPF08709; PF00520; PF02815; PF08454; PF06459; PF01365; PF02026; PF00622
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificitySkeletal muscle and brain (cerebellum and hippocampus). {ECO:0000269|PubMed:9607712}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.023529(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6UHI  (X-ray  2.88A  )  6UHS  (X-ray  2.46A  ) 
DBSNP rs193922744  rs193922746  rs193922747  rs193922748  rs118192173  rs193922752  rs118192161  rs193922753  rs193922754  rs193922755  rs193922757  rs118192115  rs112596687  rs193922760  rs1801086  rs2229140  rs193922762  rs121918592  rs113332073  rs193922764  rs193922766  rs118192117  rs118192116  rs1376393998  rs147723844  rs1008860336  rs1195513704  rs118192162  rs111888148  rs193922768  rs144336148  rs113812662  rs193922770  rs118192172  rs193922772  rs565825739  rs201401814  rs748676912  rs371278145  rs111272095  rs374776563  rs1968107192  rs35719391  rs545579559  rs34694816  rs112105381  rs137933390  rs145573319  rs34404839  rs146429605  rs146504767  rs193922779  rs34934920  rs193922784  rs367543056  rs35364374  rs746818096  rs193922788  rs117886618  rs118192175  rs118192163  rs118192163  rs118192176  rs141646642  rs118192177  rs118192177  rs193922795  rs763352221  rs140152019  rs193922797  rs34390345  rs112563513  rs147213895  rs193922798  rs193922799  rs193922801  rs193922802  rs376176332  rs746971794  rs759306349  rs146306934  rs193922807  rs976108591  rs111364296  rs193922808  rs118192174  rs193922809  rs193922810  rs121918593  rs28933396  rs28933396  rs193922812  rs118192124  rs193922816  rs118192122  rs28933397  rs121918594  rs118192178  rs118192178  rs193922818  rs2071088  rs193922821  rs756685891  rs193922826  rs112196644  rs147707463  rs2915952  rs35180584  rs112772310  rs756870293  rs2915960  rs113422327  rs200950673  rs112151058  rs367543057  rs137932199  rs367543058  rs763259167  rs118192164  rs143987857  rs55876273  rs375915752  rs4802584  rs193922839  rs763112609  rs111565359  rs193922840  rs147136339  rs193922849  rs1568576165  rs1568581848  rs193922852  rs149455643  rs73933023  rs118192130  rs118192166  rs118192134  rs118192135  rs118192138  rs118192139  rs193922863  rs193922864  rs118192141  rs193922868  rs193922867  rs193922869  rs118192179  rs118192167  rs886039586  rs118192142  rs193922874  rs118192180  rs121918595  rs1568604577  rs193922878  rs193922879  rs118192143  rs118192168  rs118192145  rs118192181  rs63749869  rs118192146  rs113210953  rs193922884  rs118192149  rs118192151  rs118192150  rs118192148  rs118192170  rs118192183  rs193922891  rs118192153  rs118192153  rs118192184  rs118192154  rs118192159  rs111657878  rs193922895  rs118192158  rs193922896  rs146876145 
Subcellular location [CC]Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:7556644};
Multi-pass membrane protein {ECO:0000305}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P11716}. Note=The number of predicted transmembrane domains varies between orthologs, but the 3D-structures show the presence of six transmembrane regions. Both N-terminus and C-terminus are cytoplasmic. {ECO:0000250|UniProtKB:P11716}.
Mouse PG classificationNA
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