| Gene Information | |
|---|---|
| Gene Name | RXRB |
| Organism | Homo sapiens (Human) |
| Gene Length | 533 |
| Protein Names | Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta) |
| Target Name | retinoic acid receptor rxr-beta |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000204231 ) 3 ( ENSG00000206289 ) 3 ( ENSG00000227322 ) 3 ( ENSG00000228333 ) 3 ( ENSG00000231321 ) 3 ( ENSG00000235712 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P28702 |
| Gene Card | RXRB |
| Uniprot ID | P28702 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (0.328616718) |
| Ortholog in Animals | Alpaca_ RXRB ( ortholog_one2one ) Dog_ RXRB ( ortholog_one2one ) GuineaPig_ RXRB ( ortholog_one2one ) Macaque_ RXRB ( ortholog_one2one ) Mouse_ Rxrb ( ortholog_one2one ) Pig_ RXRB ( ortholog_one2one ) Rat_ Rxrb ( ortholog_one2one ) Rabbit_ RXRB ( ortholog_one2one ) |
| Ohnologs | HNF4A, HNF4G, RXRA, RXRG |
| Paralogs | NR2E3, NR2F2, RXRA, HNF4A, NR2F6, HNF4G, RXRG, NR2C2, NR2C1, NR2F1, NR2E1 |
| Tissue | NA |
| Tissue Specificity | Expressed in aortic endothelial cells (at protein level) (PubMed:28167758). Expressed in monocytes (PubMed:26463675). Expressed in a variety of tumor cell lines. {ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:8381386}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.287874(Rat);0.047027(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1H9U (X-ray 2.70A ) 1UHL (X-ray 2.90A ) 5HJP (X-ray 2.60A ) 5I4V (X-ray 2.61A ) 5KYA (X-ray 2.60A ) 5KYJ (X-ray 2.80A ) 7A78 (X-ray 1.72A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:1310259, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:28167758}. |
| Mouse PG classification | NA |
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