| Gene Information | |
|---|---|
| Gene Name | RXRA |
| Organism | Homo sapiens (Human) |
| Gene Length | 462 |
| Protein Names | Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) |
| Target Name | retinoic acid receptor rxr-alpha |
| Target Type | Successful target |
| Gene Age | 810 ( ENSG00000186350 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P19793 |
| Gene Card | RXRA |
| Uniprot ID | P19793 |
| Pfam | PF00104; PF11825; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (1.379568118) |
| Ortholog in Animals | Alpaca_ RXRA ( ortholog_one2one ) Dog_ RXRA ( ortholog_one2one ) GuineaPig_ RXRA ( ortholog_one2one ) Macaque_ RXRA ( ortholog_one2one ) Mouse_ Rxra ( ortholog_one2one ) Pig_ RXRA ( ortholog_one2one ) Rat_ Rxra ( ortholog_one2one ) |
| Ohnologs | RXRG, HNF4G, RXRB |
| Paralogs | RXRB, NR2E3, NR2F2, HNF4A, NR2F6, HNF4G, RXRG, NR2C2, NR2C1, NR2F1, NR2E1 |
| Tissue | NA |
| Tissue Specificity | Expressed in lung fibroblasts (at protein level) (PubMed:30216632). Expressed in monocytes (PubMed:26463675). Highly expressed in liver, also found in kidney and brain (PubMed:24275569, PubMed:2159111, PubMed:14702039). {ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:2159111, ECO:0000269|PubMed:24275569, ECO:0000269|PubMed:26463675, ECO:0000269|PubMed:30216632}. |
| Pharmacological Animal Models | 0.118098(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BY4 (X-ray 2.10A ) 1DSZ (X-ray 1.70A ) 1FBY (X-ray 2.25A ) 1FM6 (X-ray 2.10A ) 1FM9 (X-ray 2.10A ) 1G1U (X-ray 2.50A ) 1G5Y (X-ray 2.00A ) 1K74 (X-ray 2.30A ) 1MV9 (X-ray 1.90A ) 1MVC (X-ray 1.90A ) 1MZN (X-ray 1.90A ) 1R0N (X-ray 2.60A ) 1RDT (X-ray 2.40A ) 1RXR (NMR - ) 1XLS (X-ray 2.96A ) 1XV9 (X-ray 2.70A ) 1XVP (X-ray 2.60A ) 1YNW (X-ray 3.00A ) 2ACL (X-ray 2.80A ) 2NLL (X-ray 1.90A ) 2P1T (X-ray 1.80A ) 2P1U (X-ray 2.20A ) 2P1V (X-ray 2.20A ) 2ZXZ (X-ray 3.00A ) 2ZY0 (X-ray 2.90A ) 3DZU (X-ray 3.20A ) 3DZY (X-ray 3.10A ) 3E00 (X-ray 3.10A ) 3E94 (X-ray 1.90A ) 3FAL (X-ray 2.36A ) 3FC6 (X-ray 2.06A ) 3FUG (X-ray 2.00A ) 3H0A (X-ray 2.10A ) 3KWY (X-ray 2.30A ) 3NSP (X-ray 2.90A ) 3NSQ (X-ray 2.60A ) 3OAP (X-ray 2.05A ) 3OZJ (X-ray 2.10A ) 3PCU (X-ray 2.00A ) 3R29 (X-ray 2.90A ) 3R2A (X-ray 3.00A ) 3R5M (X-ray 2.80A ) 3UVV (X-ray 2.95A ) 4CN2 (X-ray 2.07A ) 4CN3 (X-ray 2.35A ) 4CN5 (X-ray 2.00A ) 4CN7 (X-ray 2.34A ) 4J5W (X-ray 2.80A ) 4J5X (X-ray 2.80A ) 4K4J (X-ray 2.00A ) 4K6I (X-ray 2.10A ) 4M8E (X-ray 2.40A ) 4M8H (X-ray 2.20A ) 4N5G (X-ray 2.11A ) 4N8R (X-ray 2.03A ) 4NQA (X-ray 3.10A ) 4OC7 (X-ray 2.50A ) 4POH (X-ray 2.30A ) 4POJ (X-ray 2.00A ) 4PP3 (X-ray 2.00A ) 4PP5 (X-ray 2.00A ) 4RFW (X-ray 2.40A ) 4RMC (X-ray 2.70A ) 4RMD (X-ray 1.90A ) 4RME (X-ray 2.30A ) 4ZO1 (X-ray 3.22A ) 4ZSH (X-ray 1.80A ) 5EC9 (X-ray 2.30A ) 5JI0 (X-ray 1.98A ) 5LYQ (X-ray 2.17A ) 5MJ5 (X-ray 1.90A ) 5MK4 (X-ray 2.00A ) 5MKJ (X-ray 2.50A ) 5MKU (X-ray 1.78A ) 5MMW (X-ray 2.70A ) 5TBP (X-ray 2.60A ) 5UAN (X-ray 3.51A ) 5Z12 (X-ray 2.75A ) 5ZQU (X-ray 2.60A ) 6A5Y (X-ray 2.10A ) 6A5Z (X-ray 2.95A ) 6A60 (X-ray 3.05A ) 6FBQ (X-ray 1.60A ) 6FBR (X-ray 2.10A ) 6HN6 (X-ray 2.71A ) 6JNO (X-ray 2.65A ) 6JNR (X-ray 2.30A ) 6L6K (X-ray 1.80A ) 6LB4 (X-ray 1.50A ) 6LB5 (X-ray 2.40A ) 6LB6 (X-ray 2.40A ) 6SJM (X-ray 2.52A ) 6STI (X-ray 1.89A ) 6XWG (X-ray 2.40A ) 6XWH (X-ray 2.10A ) 7A77 (X-ray 1.50A ) 7B88 (X-ray 2.38A ) 7B9O (X-ray 2.05A ) 7BK4 (X-ray 2.80A ) 7CFO (X-ray 2.15A ) 7NKE (X-ray 2.35A ) |
| DBSNP | rs2234960 rs1805345 rs1805345 rs11542209 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11915042, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:28167758}. Cytoplasm {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:15509776}. Mitochondrion {ECO:0000269|PubMed:17761950}. Note=Localization to the nucleus is enhanced by vitamin D3 (PubMed:15509776). Nuclear localization may be enhanced by the interaction with heterodimerization partner VDR (PubMed:12145331). Translocation to the mitochondrion upon interaction with NR4A1 (PubMed:17761950, PubMed:15509776). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:28167758}. |
| Mouse PG classification | NA |
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