| Gene Information | |
|---|---|
| Gene Name | RUVBL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 456 |
| Protein Names | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000175792 ) 3 ( ENSG00000284901 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9Y265 |
| Gene Card | RUVBL1 |
| Uniprot ID | Q9Y265 |
| Pfam | PF06068; PF17856 |
| In ASD | yes |
| Allosteric Prediction | yes (0.56193015) |
| Ortholog in Animals | Alpaca_ RUVBL1 ( ortholog_one2one ) Dog_ RUVBL1 ( ortholog_one2one ) GuineaPig_ RUVBL1 ( ortholog_one2one ) Macaque_ RUVBL1 ( ortholog_one2one ) Mouse_ Ruvbl1 ( ortholog_one2one ) Pig_ RUVBL1 ( ortholog_one2one ) Rat_ RGD1564855 ( ortholog_one2many ) Rat_ Ruvbl1 ( ortholog_one2many ) Rabbit_ RUVBL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RUVBL2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with high expression in heart, skeletal muscle and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2C9O (X-ray 2.20A ) 2XSZ (X-ray 3.00A ) 5OAF (EM 4.06A ) 6FO1 (EM 3.57A ) 6HTS (EM 4.80A ) 6IGM (EM 4.00A ) 6K0R (X-ray 2.50A ) 6QI8 (EM 3.75A ) 6QI9 (EM 4.63A ) 7AHO (EM 4.18A ) 7OLE (EM 3.41A ) 7P6X (EM 4.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:11027681}. Membrane {ECO:0000269|PubMed:11027681}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Dynein axonemal particle {ECO:0000250|UniProtKB:Q9DE26}. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. |
| Mouse PG classification | NA |
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