| Gene Information | |
|---|---|
| Gene Name | RUSC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1516 |
| Protein Names | AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000198853 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N2Y8 |
| Gene Card | RUSC2 |
| Uniprot ID | Q8N2Y8 |
| Pfam | PF02759; PF07653 |
| In ASD | no |
| Allosteric Prediction | no (-0.998394176) |
| Ortholog in Animals | Alpaca_ RUSC2 ( ortholog_one2one ) Dog_ RUSC2 ( ortholog_one2one ) Macaque_ RUSC2 ( ortholog_one2one ) Mouse_ Rusc2 ( ortholog_one2one ) Pig_ RUSC2 ( ortholog_one2one ) Rat_ Rusc2 ( ortholog_one2one ) Rabbit_ RUSC2 ( ortholog_one2one ) |
| Ohnologs | RUSC1 |
| Paralogs | RUSC1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in brain and testis. {ECO:0000269|PubMed:15796781}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6IF2 (X-ray 2.40A ) |
| DBSNP | rs1535422 rs3750427 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:15796781}. Note=Cytosolic punctate distribution. Also observed in the perinuclear region. {ECO:0000269|PubMed:15796781}. |
| Mouse PG classification | NA |
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