| Gene Information | |
|---|---|
| Gene Name | SLC27A6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 619 |
| Protein Names | Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1) (EC 6.2.1.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000113396 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y2P4 |
| Gene Card | SLC27A6 |
| Uniprot ID | Q9Y2P4 |
| Pfam | PF00501; PF13193 |
| In ASD | no |
| Allosteric Prediction | no (-0.545192409) |
| Ortholog in Animals | Alpaca_ SLC27A6 ( ortholog_one2one ) Dog_ SLC27A6 ( ortholog_one2one ) GuineaPig_ SLC27A6 ( ortholog_one2one ) Macaque_ SLC27A6 ( ortholog_one2one ) Mouse_ Slc27a6 ( ortholog_one2one ) Pig_ SLC27A6 ( ortholog_one2one ) Rat_ Slc27a6 ( ortholog_one2one ) Rabbit_ SLC27A6 ( ortholog_one2one ) |
| Ohnologs | SLC27A2, SLC27A3 |
| Paralogs | SLC27A4, ACSBG1, ACSL1, ACSL3, SLC27A3, ACSL6, ACSBG2, ACSL4, ACSL5, SLC27A2, SLC27A1, SLC27A5 |
| Tissue | heart, testis |
| Tissue Specificity | Strongly expressed in heart and localizes to cardiac myocytes (PubMed:12556534). Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. {ECO:0000269|PubMed:12556534}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2526247 |
| Subcellular location [CC] | Cell membrane, sarcolemma {ECO:0000305|PubMed:12556534}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:E9Q9W4}; Multi-pass membrane protein {ECO:0000255}. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000305|PubMed:12556534}. |
| Mouse PG classification | NA |
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