| Gene Information | |
|---|---|
| Gene Name | RU2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 476 |
| Protein Names | Doublecortin domain-containing protein 2 (Protein RU2S) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UHG0 |
| Gene Card | DCDC2 |
| Uniprot ID | Q9UHG0 |
| Pfam | PF03607 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus (PubMed:10601354, PubMed:16278297). Expressed in liver by cholangiocytes, the epithelial cells of the bile ducts (at protein level) (PubMed:27319779). {ECO:0000269|PubMed:10601354, ECO:0000269|PubMed:16278297, ECO:0000269|PubMed:27319779}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DNF (NMR - ) |
| DBSNP | rs1042640142 rs33914824 rs2274305 rs794729665 rs9460973 |
| Subcellular location [CC] | Cell projection, cilium {ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:27319779}. Cell projection, kinocilium {ECO:0000250|UniProtKB:D3ZR10}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:D3ZR10}. Note=Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner. {ECO:0000269|PubMed:25557784}. |
| Mouse PG classification | NA |
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