| Gene Information | |
|---|---|
| Gene Name | RTRAF |
| Organism | Homo sapiens (Human) |
| Gene Length | 244 |
| Protein Names | RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000087302 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y224 |
| Gene Card | RTRAF |
| Uniprot ID | Q9Y224 |
| Pfam | PF10036 |
| In ASD | no |
| Allosteric Prediction | no (-0.87705656) |
| Ortholog in Animals | Alpaca_ RTRAF ( ortholog_one2one ) GuineaPig_ RTRAF ( ortholog_one2one ) Macaque_ RTRAF ( ortholog_one2one ) Mouse_ Rtraf ( ortholog_one2one ) Pig_ RTRAF ( ortholog_one2one ) Rat_ Rtraf ( ortholog_one2one ) Rabbit_ RTRAF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. {ECO:0000269|PubMed:15147888}. |
| Pharmacological Animal Models | 0.072395(Chimpanzee);0.037095(Mouse);0.002490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7P3A (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, cytosol {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15147888}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15147888}. Note=May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}.; Nucleus {ECO:0000269|PubMed:26864902}. Cytoplasm {ECO:0000269|PubMed:26864902}. Note=(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902). {ECO:0000269|PubMed:21900157, ECO:0000269|PubMed:26864902}. |
| Mouse PG classification | NA |
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