| Gene Information | |
|---|---|
| Gene Name | MARCHF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 289 |
| Protein Names | E3 ubiquitin-protein ligase MARCHF1 (EC 2.3.2.27) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) (RING-type E3 ubiquitin transferase MARCHF1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000145416 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TCQ1 |
| Gene Card | MARCHF1 |
| Uniprot ID | Q8TCQ1 |
| Pfam | PF12906 |
| In ASD | no |
| Allosteric Prediction | no (-1.004902831) |
| Ortholog in Animals | Alpaca_ MARCHF1 ( ortholog_one2one ) Dog_ MARCHF1 ( ortholog_one2one ) GuineaPig_ MARCHF1 ( ortholog_one2one ) Macaque_ MARCHF1 ( ortholog_one2one ) Mouse_ Marchf1 ( ortholog_one2one ) Pig_ MARCHF1 ( ortholog_one2one ) Rat_ Marchf1 ( ortholog_one2one ) Rabbit_ MARCHF1 ( ortholog_one2one ) |
| Ohnologs | MARCHF8 |
| Paralogs | MARCHF8, MARCHF9, MARCHF4, MARCHF11, MARCHF3, MARCHF2 |
| Tissue | NA |
| Tissue Specificity | Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17255932}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6NZQ8}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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