Gene Information
Gene NameRSN
OrganismHomo sapiens (Human)
Gene Length1438
Protein NamesCAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP30622
Gene CardCLIP1
Uniprot IDP30622
PfamPF01302; PF16641
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:1600942}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2CP5  (NMR  -  )  2CP6  (NMR  -  )  2E3H  (X-ray  1.45A  )  2E3I  (X-ray  2.00A  )  2E4H  (NMR  -  )  2HQH  (X-ray  1.80A  )  2QK0  (X-ray  2.00A  )  3E2U  (X-ray  2.60A  )  3RDV  (X-ray  1.75A  ) 
DBSNP rs7963597  rs3741447  rs17883517  rs1129167  rs1183319975  rs17881033 
Subcellular location [CC]Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12433698};
Peripheral membrane protein;
Cytoplasmic side. Cell projection, ruffle {ECO:0000269|PubMed:12433698}. Note=Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). {ECO:0000250|UniProtKB:Q922J3, ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404}.
Mouse PG classificationNA
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