| Gene Information | |
|---|---|
| Gene Name | CACNA1D |
| Organism | Homo sapiens (Human) |
| Gene Length | 2161 |
| Protein Names | Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3) |
| Target Name | voltage-dependent calcium channel |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000157388 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q01668 |
| Gene Card | CACNA1D |
| Uniprot ID | Q01668 |
| Pfam | PF08763; PF16885; PF16905; PF00520 |
| In ASD | yes |
| Allosteric Prediction | yes (1.295579246) |
| Ortholog in Animals | Alpaca_ CACNA1D ( ortholog_one2one ) Dog_ CACNA1D ( ortholog_one2one ) GuineaPig_ CACNA1D ( ortholog_one2one ) Macaque_ CACNA1D ( ortholog_one2one ) Mouse_ Cacna1d ( ortholog_one2one ) Pig_ CACNA1D ( ortholog_one2one ) Rat_ Cacna1d ( ortholog_one2one ) Rabbit_ CACNA1D ( ortholog_one2one ) |
| Ohnologs | CACNA1F, CACNA1C, CACNA1S |
| Paralogs | SCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A |
| Tissue | NA |
| Tissue Specificity | Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. {ECO:0000269|PubMed:1335101}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.096977(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3LV3 (X-ray 1.94A ) 7UHF (EM 3.10A ) 7UHG (EM 3.00A ) |
| DBSNP | rs1163276899 rs41276445 rs41276455 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:18482979}; Multi-pass membrane protein {ECO:0000269|PubMed:18482979}. |
| Mouse PG classification | NA |
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