| Gene Information | |
|---|---|
| Gene Name | RSAD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 361 |
| Protein Names | Radical S-adenosyl methionine domain-containing protein 2 (EC 4.2.-.-) (Cytomegalovirus-induced gene 5 protein) (Viperin) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000134321 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WXG1 |
| Gene Card | RSAD2 |
| Uniprot ID | Q8WXG1 |
| Pfam | PF04055 |
| In ASD | no |
| Allosteric Prediction | no (-0.592350963) |
| Ortholog in Animals | Alpaca_ RSAD2 ( ortholog_one2one ) Dog_ RSAD2 ( ortholog_one2one ) GuineaPig_ RSAD2 ( ortholog_one2one ) Macaque_ RSAD2 ( ortholog_one2one ) Mouse_ Rsad2 ( ortholog_one2one ) Pig_ RSAD2 ( ortholog_one2one ) Rat_ Rsad2 ( ortholog_one2one ) Rabbit_ RSAD2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17851586 rs2305257 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913, ECO:0000269|PubMed:31921110}. Endoplasmic reticulum {ECO:0000269|PubMed:11752458, ECO:0000269|PubMed:16982913, ECO:0000269|PubMed:30587778}. Lipid droplet {ECO:0000269|PubMed:31921110}. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria. |
| Mouse PG classification | NA |
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