| Gene Information | |
|---|---|
| Gene Name | RRM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 389 |
| Protein Names | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) |
| Target Name | ribonucleoside-diphosphate reductase m2 |
| Target Type | Successful target |
| Gene Age | >4290 ( ENSG00000171848 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P31350 |
| Gene Card | RRM2 |
| Uniprot ID | P31350 |
| Pfam | PF00268 |
| In ASD | no |
| Allosteric Prediction | no (-0.436008013) |
| Ortholog in Animals | Alpaca_ RRM2 ( ortholog_one2one ) Dog_ RRM2 ( ortholog_one2one ) GuineaPig_ RRM2 ( ortholog_one2one ) Macaque_ RRM2 ( ortholog_one2one ) Mouse_ Rrm2 ( ortholog_one2one ) Pig_ RRM2 ( ortholog_one2one ) Rat_ Rrm2 ( ortholog_one2one ) Rabbit_ RRM2 ( ortholog_one2one ) |
| Ohnologs | RRM2B |
| Paralogs | RRM2B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.015385(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2UW2 (X-ray 2.80A ) 3OLJ (X-ray 2.10A ) 3VPM (X-ray 2.70A ) 3VPN (X-ray 2.25A ) 3VPO (X-ray 2.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22632967}. Nucleus {ECO:0000269|PubMed:22632967}. Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. {ECO:0000269|PubMed:22632967}. |
| Mouse PG classification | NA |
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