| Gene Information | |
|---|---|
| Gene Name | RRAGA |
| Organism | Homo sapiens (Human) |
| Gene Length | 313 |
| Protein Names | Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000155876 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7L523 |
| Gene Card | RRAGA |
| Uniprot ID | Q7L523 |
| Pfam | PF04670 |
| In ASD | no |
| Allosteric Prediction | yes (0.090297194) |
| Ortholog in Animals | Alpaca_ RRAGA ( ortholog_one2one ) Dog_ RRAGA ( ortholog_one2one ) GuineaPig_ RRAGA ( ortholog_one2one ) Macaque_ RRAGA ( ortholog_one2one ) Mouse_ Rraga ( ortholog_one2one ) Pig_ RRAGA ( ortholog_one2one ) Rat_ Rraga ( ortholog_one2one ) Rabbit_ RRAGA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RRAGB, RRAGD, RRAGC |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. {ECO:0000269|PubMed:8995684}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.103759(Rat);0.138240(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5X6V (X-ray 2.02A ) 6CES (EM 4.00A ) 6EHR (X-ray 2.90A ) 6NZD (EM 3.60A ) 6S6A (X-ray 2.63A ) 6S6D (X-ray 2.50A ) 6SB0 (EM 5.50A ) 6SB2 (EM 6.20A ) 6U62 (EM 3.18A ) 6ULG (EM 3.31A ) 6WJ2 (EM 3.20A ) 6WJ3 (EM 3.90A ) 7T3A (EM 4.00A ) 7T3B (EM 3.90A ) 7T3C (EM 4.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. Nucleus {ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. Lysosome {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:31036939}. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:8995684, ECO:0000269|PubMed:9394008}. |
| Mouse PG classification | NA |
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