| Gene Information | |
|---|---|
| Gene Name | TPSB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 275 |
| Protein Names | Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II) |
| Target Name | tryptase beta-2 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000197253 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P20231 |
| Gene Card | TPSB2 |
| Uniprot ID | P20231 |
| Pfam | PF00089 |
| In ASD | yes |
| Allosteric Prediction | yes (0.92603158) |
| Ortholog in Animals | Alpaca_ TPSB2 ( ortholog_one2many ) Mouse_ Tpsb2 ( ortholog_many2many ) Mouse_ Tpsab1 ( ortholog_many2many ) Rat_ Tpsb2 ( ortholog_many2many ) Rat_ Tpsab1 ( ortholog_many2many ) |
| Ohnologs | TMPRSS2, TMPRSS5 |
| Paralogs | TPSD1, TPSG1, TPSAB1 |
| Tissue | lung, pancreas, sigmoid.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A0L (X-ray 3.00A ) 2BM2 (X-ray 2.20A ) 2FPZ (X-ray 2.00A ) 2FS8 (X-ray 2.50A ) 2FS9 (X-ray 2.30A ) 2FWW (X-ray 2.25A ) 2FXR (X-ray 2.50A ) 2GDD (X-ray 2.35A ) 2ZA5 (X-ray 2.30A ) 3V7T (X-ray 2.09A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. Note=Released from the secretory granules upon mast cell activation. |
| Mouse PG classification | NA |
| click here to return to the previous page | |