| Gene Information | |
|---|---|
| Gene Name | TRAM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1424 |
| Protein Names | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000067167 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y6Q9 |
| Gene Card | NCOA3 |
| Uniprot ID | Q9Y6Q9 |
| Pfam | PF07469; PF16279; PF08815; PF00989; PF08832 |
| In ASD | no |
| Allosteric Prediction | no (-0.820958524) |
| Ortholog in Animals | Alpaca_ TRAM1 ( ortholog_one2one ) Dog_ TRAM1 ( ortholog_one2one ) GuineaPig_ TRAM1 ( ortholog_one2one ) Macaque_ TRAM1 ( ortholog_one2one ) Mouse_ Tram1 ( ortholog_one2one ) Pig_ TRAM1 ( ortholog_one2one ) Rat_ Tram1 ( ortholog_one2one ) Rabbit_ TRAM1 ( ortholog_one2one ) |
| Ohnologs | TRAM2 |
| Paralogs | TRAM1L1, TRAM2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney. |
| Pharmacological Animal Models | 0.150189(Chimpanzee);0.079988(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KBH (NMR - ) 3L3X (X-ray 1.55A ) 3L3Z (X-ray 2.00A ) 6ES7 (NMR - ) 6SQC (X-ray 2.28A ) |
| DBSNP | rs6094752 rs72645252 rs6094756 rs1052765 rs72645272 rs2230781 rs2230782 rs2230783 rs72645299 rs72645298 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus. |
| Mouse PG classification | NA |
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