| Gene Information | |
|---|---|
| Gene Name | SLFN11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 901 |
| Protein Names | Schlafen family member 11 (EC 3.6.-.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000172716 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q7Z7L1 |
| Gene Card | SLFN11 |
| Uniprot ID | Q7Z7L1 |
| Pfam | PF04326; PF09848 |
| In ASD | no |
| Allosteric Prediction | no (-1.342755331) |
| Ortholog in Animals | Alpaca_ SLFN11 ( ortholog_one2one ) Mouse_ Slfn9 ( ortholog_many2many ) Mouse_ Slfn8 ( ortholog_many2many ) Rat_ Slfn13 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | SLFN13, SLFN12L, SLFN5, SLFN12, SLFN14, SLFNL1 |
| Tissue | NA |
| Tissue Specificity | Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues. {ECO:0000269|PubMed:22927417}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12453150 rs4796077 rs9898983 rs3803860 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. Chromosome {ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. Note=Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061). {ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. |
| Mouse PG classification | NA |
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