| Gene Information | |
|---|---|
| Gene Name | STAG3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1225 |
| Protein Names | Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000066923 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UJ98 |
| Gene Card | STAG3 |
| Uniprot ID | Q9UJ98 |
| Pfam | PF08514 |
| In ASD | no |
| Allosteric Prediction | no (-0.097358529) |
| Ortholog in Animals | Alpaca_ STAG3 ( ortholog_one2one ) Dog_ STAG3 ( ortholog_one2one ) GuineaPig_ STAG3 ( ortholog_one2one ) Macaque_ STAG3 ( ortholog_one2one ) Mouse_ Stag3 ( ortholog_one2one ) Pig_ STAG3 ( ortholog_one2one ) Rat_ Stag3 ( ortholog_one2one ) Rabbit_ STAG3 ( ortholog_one2one ) |
| Ohnologs | STAG2, STAG1 |
| Paralogs | STAG2, STAG1 |
| Tissue | testis |
| Tissue Specificity | Testis specific. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750, ECO:0000269|PubMed:12034751}. Chromosome {ECO:0000269|PubMed:12034751}. Chromosome, centromere {ECO:0000269|PubMed:12034751}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation. {ECO:0000269|PubMed:12034751}. |
| Mouse PG classification | NA |
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