| Gene Information | |
|---|---|
| Gene Name | PLP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | Myelin proteolipid protein (PLP) (Lipophilin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000123560 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P60201 |
| Gene Card | PLP1 |
| Uniprot ID | P60201 |
| Pfam | PF01275 |
| In ASD | no |
| Allosteric Prediction | no (-0.308707377) |
| Ortholog in Animals | Alpaca_ PLP1 ( ortholog_one2one ) Dog_ PLP1 ( ortholog_one2one ) GuineaPig_ PLP1 ( ortholog_one2one ) Macaque_ PLP1 ( ortholog_one2one ) Mouse_ Plp1 ( ortholog_one2one ) Pig_ PLP1 ( ortholog_one2one ) Rat_ Plp1 ( ortholog_one2one ) Rabbit_ PLP1 ( ortholog_one2one ) |
| Ohnologs | GPM6B, GPM6A |
| Paralogs | GPM6B, GPM6A |
| Tissue | cerebral.cortex, substantia.nigra, brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XPG (X-ray 2.60A ) |
| DBSNP | rs11543022 rs1064794255 rs132630289 rs132630285 rs878853076 rs132630295 rs132630287 rs132630280 rs132630279 rs132630294 rs132630282 rs132630288 rs132630284 rs132630284 rs132630278 rs132630281 rs132630286 rs132630283 rs398123466 rs132630291 rs398123467 rs886043504 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24103481}; Multi-pass membrane protein {ECO:0000269|PubMed:24103481}. Myelin membrane {ECO:0000250}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat. {ECO:0000250}. |
| Mouse PG classification | NA |
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