Gene Information
Gene NameNR1D2
OrganismHomo sapiens (Human)
Gene Length579
Protein NamesNuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
Target Namenuclear receptor subfamily 1 group d member 2
Target TypeNA
Gene Age810 ( ENSG00000174738 )
Evolutionary StageEumetazoa
AlphaFoldDBQ14995
Gene CardNR1D2
Uniprot IDQ14995
PfamPF00104; PF00105
In ASDno
Allosteric Predictionno (-0.500138545)
Ortholog in AnimalsAlpaca_ NR1D2 ( ortholog_one2one )
Dog_ NR1D2 ( ortholog_one2one )
GuineaPig_ NR1D2 ( ortholog_one2one )
Macaque_ NR1D2 ( ortholog_one2one )
Mouse_ Nr1d2 ( ortholog_one2one )
Pig_ NR1D2 ( ortholog_one2one )
Rat_ Nr1d2 ( ortholog_one2one )
Rabbit_ NR1D2 ( ortholog_one2one )
OhnologsNR1D1
ParalogsNR1H4, VDR, RARG, RARA, PPARD, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA, THRA
TissueNA
Tissue SpecificityWidely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2V0V  (X-ray  2.40A  )  2V7C  (X-ray  2.40A  )  3CQV  (X-ray  1.90A  )  4N73  (X-ray  1.87A  )  6WMQ  (X-ray  2.55A  )  6WMS  (X-ray  2.00A  ) 
DBSNP rs17854365  rs17857305  rs17857306  rs4858097 
Subcellular location [CC]Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:17892483, ECO:0000269|PubMed:17996965}. Cytoplasm {ECO:0000250|UniProtKB:Q60674}. Note=Phosphorylation by CSNK1E enhances its cytoplasmic localization. {ECO:0000250|UniProtKB:Q60674}.
Mouse PG classificationNA
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