Gene Information
Gene NameRPE65
OrganismHomo sapiens (Human)
Gene Length533
Protein NamesRetinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase)
Target Nameretinal pigment epithelium protein
Target TypeClinical trial target
Gene Age950 ( ENSG00000116745 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ16518
Gene CardRPE65
Uniprot IDQ16518
PfamPF03055
In ASDno
Allosteric Predictionno (-0.000178282)
Ortholog in AnimalsAlpaca_ RPE65 ( ortholog_one2one )
Dog_ RPE65 ( ortholog_one2one )
GuineaPig_ RPE65 ( ortholog_one2one )
Macaque_ RPE65 ( ortholog_one2one )
Mouse_ Rpe65 ( ortholog_one2one )
Pig_ RPE65 ( ortholog_one2one )
Rat_ Rpe65 ( ortholog_one2one )
Rabbit_ RPE65 ( ortholog_one2one )
OhnologsNA
ParalogsBCO2, BCO1
TissueNA
Tissue SpecificityRetina (at protein level). Retinal pigment epithelium specific. {ECO:0000269|PubMed:17848510, ECO:0000269|PubMed:21493626}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs61751277  rs61751281  rs61751282  rs1266217912  rs1344724754  rs61752866  rs61752869  rs61752870  rs61752873  rs61752873  rs61752871  rs61752874  rs143056561  rs1444234037  rs62642584  rs61752876  rs61752878  rs61752880  rs61752882  rs774309607  rs61752883  rs61752884  rs61752884  rs61752896  rs281865289  rs61752901  rs1375943362  rs61752905  rs149916178  rs61752908  rs1459522532  rs61752909  rs121917744  rs62653012  rs62653011  rs62635773  rs62636298  rs62636299  rs62636300  rs34627040  rs62636302  rs62637002  rs1645824187  rs62637004  rs774211361  rs62637007  rs1571158279  rs121917745  rs1193631220  rs577335767 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:A9C3R9}. Cell membrane {ECO:0000269|PubMed:19049981};
Lipid-anchor {ECO:0000269|PubMed:19049981}. Microsome membrane {ECO:0000250|UniProtKB:Q28175}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells. {ECO:0000269|PubMed:19049981, ECO:0000269|PubMed:21493626}.
Mouse PG classificationHPG
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