Gene Information
Gene NamePDE11A
OrganismHomo sapiens (Human)
Gene Length933
Protein NamesDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)
Target Namecyclic nucleotide phosphodiesterase
Target TypeNA
Gene Age680 ( ENSG00000128655 )
Evolutionary StageEukaryota
AlphaFoldDBQ9HCR9
Gene CardPDE11A
Uniprot IDQ9HCR9
PfamPF01590; PF00233
In ASDyes
Allosteric Predictionyes (0.999970304)
Ortholog in AnimalsAlpaca_ PDE11A ( ortholog_one2one )
Dog_ PDE11A ( ortholog_one2one )
GuineaPig_ PDE11A ( ortholog_one2one )
Macaque_ PDE11A ( ortholog_one2one )
Mouse_ Pde11a ( ortholog_one2one )
Pig_ PDE11A ( ortholog_one2one )
Rat_ Cyct ( ortholog_one2one )
OhnologsPDE5A
ParalogsPDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C
Tissuepancreas, prostate
Tissue SpecificityIsoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:11121118, ECO:0000269|PubMed:15800651, ECO:0000269|PubMed:16079899, ECO:0000269|PubMed:16767104}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs75127279  rs61306957 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}.
Mouse PG classificationNA
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