Gene Information
Gene NameROS1
OrganismHomo sapiens (Human)
Gene Length2347
Protein NamesProto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)
Target Nameproto-oncogene c-ros
Target TypeSuccessful target
Gene Age645 ( ENSG00000047936 )
Evolutionary StageOpisthokonta
AlphaFoldDBP08922
Gene CardROS1
Uniprot IDP08922
PfamPF00041; PF07714
In ASDno
Allosteric Predictionyes (0.372067068)
Ortholog in AnimalsAlpaca_ ROS1 ( ortholog_one2one )
Dog_ ROS1 ( ortholog_one2one )
Macaque_ ROS1 ( ortholog_one2one )
Mouse_ Ros1 ( ortholog_one2one )
Pig_ ROS1 ( ortholog_one2one )
Rat_ Ros1 ( ortholog_one2one )
Rabbit_ ROS1 ( ortholog_one2one )
OhnologsNA
ParalogsEPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
Tissuelung
Tissue SpecificityExpressed in brain. Expression is increased in primary gliomas. {ECO:0000269|PubMed:8143271}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3ZBF  (X-ray  2.20A  )  4UXL  (X-ray  2.40A  )  7Z5W  (X-ray  2.25A  )  7Z5X  (X-ray  2.04A  ) 
DBSNP rs45606237  rs34245787  rs1998206  rs2243380  rs55959124  rs55707658  rs56274823  rs1444274116  rs28639589  rs34203286  rs34582164  rs2229079  rs56192249  rs35269727  rs36106063  rs17079086  rs35841892  rs12664076  rs9489124  rs45569132  rs3752566  rs556427413  rs75510639  rs529038  rs529156  rs619203  rs210968  rs35932630 
Subcellular location [CC]Cell membrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}.
Mouse PG classificationNA
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