| Gene Information | |
|---|---|
| Gene Name | RORA |
| Organism | Homo sapiens (Human) |
| Gene Length | 523 |
| Protein Names | Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha) |
| Target Name | nuclear receptor ror-alpha |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000069667 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35398 |
| Gene Card | RORA |
| Uniprot ID | P35398 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (0.468015142) |
| Ortholog in Animals | Alpaca_ RORA ( ortholog_one2one ) Dog_ RORA ( ortholog_one2one ) GuineaPig_ RORA ( ortholog_one2one ) Macaque_ RORA ( ortholog_one2one ) Mouse_ Rora ( ortholog_one2one ) Pig_ RORA ( ortholog_one2one ) Rat_ Rora ( ortholog_one2one ) Rabbit_ RORA ( ortholog_one2one ) |
| Ohnologs | RORC, RORB |
| Paralogs | NR1H4, VDR, RARG, NR1D2, RARA, PPARD, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, THRA |
| Tissue | NA |
| Tissue Specificity | Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff) (PubMed:18354202, PubMed:7916608). Isoform 4: Highly expressed in the central nervous system, including in the cerebellum (PubMed:29656859). {ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:29656859, ECO:0000269|PubMed:7916608}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.175650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1N83 (X-ray 1.63A ) 1S0X (X-ray 2.20A ) 4S15 (X-ray 1.90A ) |
| DBSNP | rs1555427498 rs1555427497 rs1433850094 rs190933482 rs1332895658 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046}. |
| Mouse PG classification | NA |
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