| Gene Information | |
|---|---|
| Gene Name | ROR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 943 |
| Protein Names | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) |
| Target Name | neurotrophic tyrosine kinase ror2 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000169071 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q01974 |
| Gene Card | ROR2 |
| Uniprot ID | Q01974 |
| Pfam | PF01392; PF07679; PF00051; PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.565643644) |
| Ortholog in Animals | Alpaca_ ROR2 ( ortholog_one2one ) Dog_ ROR2 ( ortholog_one2one ) GuineaPig_ ROR2 ( ortholog_one2one ) Macaque_ ROR2 ( ortholog_one2one ) Mouse_ Ror2 ( ortholog_one2one ) Pig_ ROR2 ( ortholog_one2one ) Rat_ Ror2 ( ortholog_one2one ) Rabbit_ ROR2 ( ortholog_one2one ) |
| Ohnologs | ROR1 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET, ROR1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ZZW (X-ray 2.90A ) 4GT4 (X-ray 2.41A ) 6OSH (X-ray 1.12A ) 6OSN (X-ray 1.08A ) 6OSV (X-ray 1.34A ) |
| DBSNP | rs121909084 rs199975149 rs55737262 rs10820900 rs55983376 rs56197744 rs35852786 rs140213020 rs35764413 rs56099091 rs55798732 rs55651110 rs34431454 rs56231927 rs34491822 rs10761129 rs41277835 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Mouse PG classification | HPG |
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