| Gene Information | |
|---|---|
| Gene Name | RO52 |
| Organism | Homo sapiens (Human) |
| Gene Length | 475 |
| Protein Names | E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (RING-type E3 ubiquitin transferase TRIM21) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P19474 |
| Gene Card | TRIM21 |
| Uniprot ID | P19474 |
| Pfam | PF13765; PF00622; PF00643; PF00097 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in fetal and adult heart and fetal lung. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001860(Rat);0.024(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IWG (X-ray 2.35A ) 5JPX (NMR - ) 5OLM (X-ray 1.95A ) 6FGA (X-ray 2.82A ) 6S53 (X-ray 2.80A ) 7BBD (X-ray 2.20A ) |
| DBSNP | rs1042302 rs58403334 rs2975162 rs2554934 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:26347139}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26347139}. Nucleus {ECO:0000269|PubMed:17156811}. Cytoplasm, P-body {ECO:0000269|PubMed:18361920}. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called processing bodies (P-bodies) that are located underneath the plasma membrane and also diffusely in the cytoplasm. They are located along the microtubules and are highly motile in cells. Colocalizes with DCP2 in P-bodies. |
| Mouse PG classification | NA |
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