| Gene Information | |
|---|---|
| Gene Name | RNS6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 150 |
| Protein Names | Ribonuclease K6 (RNase K6) (EC 3.1.27.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q93091 |
| Gene Card | RNASE6 |
| Uniprot ID | Q93091 |
| Pfam | PF00074 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in spleen (at protein level) (PubMed:8836175, PubMed:25075772). Has little or no expression in healthy kidneys (at protein level) (PubMed:25075772). Detected in interstitial leukocytes in infected kidneys (at protein level) (PubMed:25075772). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level) (PubMed:25075772). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle (PubMed:8836175, PubMed:25075772). Also expressed in monocytes and neutrophils (PubMed:8836175). {ECO:0000269|PubMed:25075772, ECO:0000269|PubMed:8836175}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4X09 (X-ray 1.72A ) 5OAB (X-ray 1.11A ) 6ENP (X-ray 1.04A ) 6MV6 (X-ray 1.50A ) 6MV7 (X-ray 2.59A ) |
| DBSNP | rs1045922 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:25075772}. Lysosome {ECO:0000305|PubMed:25075772}. Cytoplasmic granule {ECO:0000269|PubMed:25075772}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |