| Gene Information | |
|---|---|
| Gene Name | MECR |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase) (Nuclear receptor-binding factor 1) (HsNrbf-1) (NRBF-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000116353 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9BV79 |
| Gene Card | MECR |
| Uniprot ID | Q9BV79 |
| Pfam | PF08240; PF00107 |
| In ASD | no |
| Allosteric Prediction | no (-0.915410984) |
| Ortholog in Animals | Alpaca_ MECR ( ortholog_one2one ) Dog_ MECR ( ortholog_one2one ) GuineaPig_ MECR ( ortholog_one2one ) Macaque_ MECR ( ortholog_one2one ) Mouse_ Mecr ( ortholog_one2one ) Pig_ MECR ( ortholog_one2one ) Rat_ Mecr ( ortholog_one2one ) Rabbit_ MECR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRYZ, RTN4IP1, PTGR2, TP53I3, CRYZL1, PTGR3, ADH6, ADH4, SORD, ADH1B, ADH1A, ADH1C, VAT1L, PTGR1, ADH5, ADH7, VAT1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung. {ECO:0000269|PubMed:12654921}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZSY (X-ray 1.75A ) 2VCY (X-ray 2.41A ) 7AYB (X-ray 1.85A ) 7AYC (X-ray 2.02A ) |
| DBSNP | rs1128400 rs11544658 rs762913101 rs34835902 rs145192716 rs759218713 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12654921}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25031892}. Nucleus {ECO:0000269|PubMed:25031892}. |
| Mouse PG classification | NA |
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