| Gene Information | |
|---|---|
| Gene Name | PRKCQ |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) |
| Target Name | protein kinase c theta type |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000065675 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q04759 |
| Gene Card | PRKCQ |
| Uniprot ID | Q04759 |
| Pfam | PF00130; PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | yes (1.722159818) |
| Ortholog in Animals | Alpaca_ PRKCQ ( ortholog_one2one ) Dog_ PRKCQ ( ortholog_one2one ) GuineaPig_ PRKCQ ( ortholog_one2one ) Macaque_ PRKCQ ( ortholog_one2one ) Mouse_ Prkcq ( ortholog_one2one ) Pig_ PRKCQ ( ortholog_one2one ) Rat_ Prkcq ( ortholog_one2one ) Rabbit_ PRKCQ ( ortholog_one2one ) |
| Ohnologs | PRKCD |
| Paralogs | AKT3, PDPK1, AKT1, AKT2, PRKCD |
| Tissue | skeletal.muscle |
| Tissue Specificity | Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets. {ECO:0000269|PubMed:7686153}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1XJD (X-ray 2.00A ) 2ENJ (NMR - ) 2ENN (NMR - ) 2ENZ (NMR - ) 2JED (X-ray 2.32A ) 4Q9Z (X-ray 2.60A ) 4RA5 (X-ray 2.61A ) 5F9E (X-ray 2.00A ) |
| DBSNP | rs45590231 rs2236379 rs34524148 |
| Subcellular location [CC] | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse. |
| Mouse PG classification | NA |
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