| Gene Information | |
|---|---|
| Gene Name | RNGTT |
| Organism | Homo sapiens (Human) |
| Gene Length | 597 |
| Protein Names | mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000111880 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60942 |
| Gene Card | RNGTT |
| Uniprot ID | O60942 |
| Pfam | PF00782; PF03919; PF01331 |
| In ASD | no |
| Allosteric Prediction | yes (0.324459143) |
| Ortholog in Animals | Alpaca_ RNGTT ( ortholog_one2one ) Dog_ RNGTT ( ortholog_one2one ) GuineaPig_ RNGTT ( ortholog_one2one ) Macaque_ RNGTT ( ortholog_one2one ) Mouse_ Rngtt ( ortholog_one2one ) Pig_ RNGTT ( ortholog_one2one ) Rat_ Rngtt ( ortholog_one2one ) Rabbit_ RNGTT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DUSP11 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.008696(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2C46 (X-ray 1.60A ) 3S24 (X-ray 3.01A ) |
| DBSNP | rs17856595 |
| Subcellular location [CC] | Nucleus {ECO:0000250}. |
| Mouse PG classification | NA |
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