| Gene Information | |
|---|---|
| Gene Name | RNFT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 435 |
| Protein Names | E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000189050 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5M7Z0 |
| Gene Card | RNFT1 |
| Uniprot ID | Q5M7Z0 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.786224235) |
| Ortholog in Animals | Alpaca_ RNFT1 ( ortholog_one2one ) Dog_ RNFT1 ( ortholog_one2one ) GuineaPig_ RNFT1 ( ortholog_one2one ) Macaque_ RNFT1 ( ortholog_one2one ) Mouse_ Rnft1 ( ortholog_one2one ) Pig_ RNFT1 ( ortholog_one2one ) Rat_ Rnft1 ( ortholog_one2one ) |
| Ohnologs | RNFT2 |
| Paralogs | RNFT2 |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in testis, lower levels in heart, liver, lung, and kidney (PubMed:17074343). Not detected in brain, ovary, and uterus (PubMed:17074343). Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS) (PubMed:17074343). Ubiquitously expressed with high expression in testis (PubMed:27485036). {ECO:0000269|PubMed:17074343, ECO:0000269|PubMed:27485036}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |