| Gene Information | |
|---|---|
| Gene Name | RNF88 |
| Organism | Homo sapiens (Human) |
| Gene Length | 493 |
| Protein Names | Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9C035 |
| Gene Card | TRIM5 |
| Uniprot ID | Q9C035 |
| Pfam | PF00622; PF00643; PF13445 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ECV (NMR - ) 2YRG (NMR - ) |
| DBSNP | rs59896509 rs3740996 rs61432120 rs56348930 rs11601507 rs10838525 rs11038628 rs28381981 rs59218593 rs7104422 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:25127057}. Nucleus {ECO:0000250|UniProtKB:Q0PF16}. Note=Predominantly localizes in cytoplasmic bodies (PubMed:12878161, PubMed:20357094). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (By similarity). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (By similarity). {ECO:0000250|UniProtKB:Q0PF16, ECO:0000269|PubMed:12878161, ECO:0000269|PubMed:20357094, ECO:0000269|PubMed:25127057}. |
| Mouse PG classification | NA |
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