| Gene Information | |
|---|---|
| Gene Name | RNF85 |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y4K3 |
| Gene Card | TRAF6 |
| Uniprot ID | Q9Y4K3 |
| Pfam | PF18048; PF02176 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066155(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LB4 (X-ray 2.40A ) 1LB5 (X-ray 2.40A ) 1LB6 (X-ray 1.80A ) 2ECI (NMR - ) 2JMD (NMR - ) 3HCS (X-ray 2.20A ) 3HCT (X-ray 2.10A ) 3HCU (X-ray 2.60A ) 4Z8M (X-ray 2.95A ) 5ZUJ (X-ray 2.60A ) 6A33 (X-ray 2.10A ) 7L3L (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18093978, ECO:0000269|PubMed:23514740}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250|UniProtKB:P70196}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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