| Gene Information | |
|---|---|
| Gene Name | RNF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 485 |
| Protein Names | E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000112130 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O76064 |
| Gene Card | RNF8 |
| Uniprot ID | O76064 |
| Pfam | PF00498 |
| In ASD | no |
| Allosteric Prediction | yes (0.003836327) |
| Ortholog in Animals | Alpaca_ RNF8 ( ortholog_one2one ) GuineaPig_ RNF8 ( ortholog_one2one ) Mouse_ Rnf8 ( ortholog_one2one ) Pig_ RNF8 ( ortholog_one2one ) Rat_ Rnf8 ( ortholog_one2one ) Rabbit_ RNF8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. In fetal tissues, highest expression in brain, thymus and liver. In adult tissues, highest levels in brain and testis, lowest levels in peripheral blood cells. {ECO:0000269|PubMed:16215985, ECO:0000269|PubMed:9852682}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.006900(Mouse);0.001407(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CSW (NMR - ) 2PIE (X-ray 1.35A ) 4AYC (X-ray 1.90A ) 4ORH (X-ray 4.80A ) 4WHV (X-ray 8.30A ) |
| DBSNP | rs34338974 rs1139944 |
| Subcellular location [CC] | Nucleus {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:11322894, ECO:0000269|PubMed:14981089, ECO:0000269|PubMed:16215985, ECO:0000269|PubMed:23233665}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03067}. Midbody {ECO:0000255|HAMAP-Rule:MF_03067}. Chromosome, telomere {ECO:0000255|HAMAP-Rule:MF_03067}. Note=Recruited at uncapped telomeres (By similarity). Following DNA damage, such as double-strand breaks, recruited to the sites of damage (PubMed:18001824, PubMed:18077395, PubMed:22266820, PubMed:23233665). During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1. {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:18001824, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:22266820, ECO:0000269|PubMed:23233665}. |
| Mouse PG classification | NA |
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