| Gene Information | |
|---|---|
| Gene Name | RNF6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 685 |
| Protein Names | E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000127870 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y252 |
| Gene Card | RNF6 |
| Uniprot ID | Q9Y252 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.383462852) |
| Ortholog in Animals | Alpaca_ RNF6 ( ortholog_one2one ) Dog_ RNF6 ( ortholog_one2one ) GuineaPig_ RNF6 ( ortholog_one2one ) Macaque_ RNF6 ( ortholog_one2one ) Mouse_ Rnf6 ( ortholog_one2one ) Pig_ RNF6 ( ortholog_one2one ) Rat_ Rnf6 ( ortholog_one2one ) |
| Ohnologs | RLIM |
| Paralogs | RNF44, RLIM, RNF38 |
| Tissue | NA |
| Tissue Specificity | Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues. {ECO:0000269|PubMed:18368307, ECO:0000269|PubMed:19345326}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3910433 rs121434522 rs61760897 rs7990167 rs121434523 rs121434524 rs138379662 rs17083436 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19345326}. Cytoplasm {ECO:0000269|PubMed:19345326}. Cell projection, axon {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250}. |
| Mouse PG classification | NA |
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