| Gene Information | |
|---|---|
| Gene Name | RNF59 |
| Organism | Homo sapiens (Human) |
| Gene Length | 667 |
| Protein Names | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O15344 |
| Gene Card | MID1 |
| Uniprot ID | O15344 |
| Pfam | PF18568; PF00041; PF13765; PF00622; PF00643; PF13445 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001615(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DQ5 (NMR - ) 2FFW (NMR - ) 2JUN (NMR - ) 5IM8 (NMR - ) 7QRY (X-ray 2.07A ) |
| DBSNP | rs104894866 rs28934611 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10077590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10077590}. Note=Microtubule-associated. It is associated with microtubules throughout the cell cycle, co-localizing with cytoplasmic fibers in interphase and with the mitotic spindle and midbodies during mitosis and cytokinesis. |
| Mouse PG classification | NA |
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