| Gene Information | |
|---|---|
| Gene Name | RNF43 |
| Organism | Homo sapiens (Human) |
| Gene Length | 783 |
| Protein Names | E3 ubiquitin-protein ligase RNF43 (EC 2.3.2.27) (RING finger protein 43) (RING-type E3 ubiquitin transferase RNF43) |
| Target Name | ring finger protein 43 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000108375 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q68DV7 |
| Gene Card | RNF43 |
| Uniprot ID | Q68DV7 |
| Pfam | PF13639; PF18212 |
| In ASD | no |
| Allosteric Prediction | no (-0.639332906) |
| Ortholog in Animals | Alpaca_ RNF43 ( ortholog_one2one ) Dog_ RNF43 ( ortholog_one2one ) GuineaPig_ RNF43 ( ortholog_one2one ) Macaque_ RNF43 ( ortholog_one2one ) Mouse_ Rnf43 ( ortholog_one2one ) Pig_ RNF43 ( ortholog_one2one ) Rat_ Rnf43 ( ortholog_one2one ) Rabbit_ RNF43 ( ortholog_one2one ) |
| Ohnologs | ZNRF3 |
| Paralogs | ZNRF3 |
| Tissue | NA |
| Tissue Specificity | Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. {ECO:0000269|PubMed:15492824, ECO:0000269|PubMed:18313049}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4KNG (X-ray 2.50A ) |
| DBSNP | rs3744093 rs2257205 rs2285990 rs2680701 rs34523089 rs2526374 rs9652855 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269|PubMed:15492824}. |
| Mouse PG classification | NA |
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