| Gene Information | |
|---|---|
| Gene Name | EPHA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 976 |
| Protein Names | Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) |
| Target Name | ephrin type-a receptor 1 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000146904 ) 3 ( ENSG00000284816 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P21709 |
| Gene Card | EPHA1 |
| Uniprot ID | P21709 |
| Pfam | PF14575; PF01404; PF07699; PF00041; PF07714; PF00536 |
| In ASD | no |
| Allosteric Prediction | no (-0.653488789) |
| Ortholog in Animals | Alpaca_ EPHA1 ( ortholog_one2many ) Dog_ EPHA1 ( ortholog_one2one ) GuineaPig_ EPHA1 ( ortholog_one2one ) Macaque_ EPHA1 ( ortholog_one2one ) Mouse_ Epha1 ( ortholog_one2one ) Pig_ EPHA1 ( ortholog_one2one ) Rat_ Epha1 ( ortholog_one2one ) Rabbit_ EPHA1 ( ortholog_one2one ) |
| Ohnologs | EPHB4, EPHA8, EPHA4, EPHB2, EPHA2, EPHB1, EPHB3 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, MET |
| Tissue | NA |
| Tissue Specificity | Overexpressed in several carcinomas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K1K (NMR - ) 2K1L (NMR - ) 3HIL (X-ray 2.00A ) 3KKA (X-ray 2.40A ) |
| DBSNP | rs4725617 rs56006153 rs11768549 rs35719334 rs34178823 rs34372369 rs56244405 rs6967117 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}. |
| Mouse PG classification | NA |
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