Gene Information
Gene NameRNF2
OrganismHomo sapiens (Human)
Gene Length336
Protein NamesE3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000121481 )
Evolutionary StageEukaryota
AlphaFoldDBQ99496
Gene CardRNF2
Uniprot IDQ99496
PfamPF16207
In ASDno
Allosteric Predictionyes (0.570161899)
Ortholog in AnimalsAlpaca_ RNF2 ( ortholog_one2one )
Dog_ RNF2 ( ortholog_one2one )
GuineaPig_ RNF2 ( ortholog_one2one )
Macaque_ RNF2 ( ortholog_one2one )
Mouse_ Rnf2 ( ortholog_one2one )
Pig_ RNF2 ( ortholog_one2one )
Rat_ Rnf2 ( ortholog_one2one )
OhnologsRING1
ParalogsPCGF3, PCGF5, PCGF6, BMI1, RING1, PCGF1, PCGF2
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.037681(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2H0D  (X-ray  2.50A  )  3GS2  (X-ray  1.70A  )  3H8H  (X-ray  2.00A  )  3IXS  (X-ray  1.70A  )  3RPG  (X-ray  2.65A  )  4R8P  (X-ray  3.28A  )  4S3O  (X-ray  2.00A  )  6WI7  (X-ray  1.70A  )  6WI8  (X-ray  3.09A  )  7ND1  (NMR  -  ) 
DBSNP rs1651767648 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:21282530}. Cytoplasm {ECO:0000250|UniProtKB:Q9CQJ4}. Chromosome {ECO:0000250|UniProtKB:Q9CQJ4}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. {ECO:0000250|UniProtKB:Q9CQJ4}.
Mouse PG classificationNA
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