Gene Information
Gene NamePTEN
OrganismHomo sapiens (Human)
Gene Length403
Protein NamesPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Target Namephosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten
Target TypeNA
Gene Age70 ( ENSG00000171862 )
3 ( ENSG00000284792 )
Evolutionary StageEukaryota
AlphaFoldDBP60484
Gene CardPTEN
Uniprot IDP60484
PfamPF10409
In ASDyes
Allosteric Predictionyes (2.086920857)
Ortholog in AnimalsAlpaca_ PTEN ( ortholog_one2one )
Dog_ PTEN ( ortholog_one2one )
GuineaPig_ PTEN ( ortholog_one2one )
Mouse_ Pten ( ortholog_one2one )
Rabbit_ PTEN ( ortholog_one2one )
OhnologsNA
ParalogsTNS1, HVCN1, TMEM266, TNS3, TPTE, TPTE2
TissueNA
Tissue SpecificityExpressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. {ECO:0000269|PubMed:9090379}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.039216(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1D5R  (X-ray  2.10A  )  2KYL  (NMR  -  )  4O1V  (X-ray  2.00A  )  5BUG  (X-ray  2.40A  )  5BZX  (X-ray  2.50A  )  5BZZ  (X-ray  2.20A  )  7JTX  (X-ray  3.23A  )  7JUK  (X-ray  3.15A  )  7JUL  (X-ray  2.53A  )  7JVX  (X-ray  3.20A  )  7PC7  (X-ray  2.10A  ) 
DBSNP rs1064794096  rs121909233  rs1064795967  rs886041877  rs1554893765  rs121909225  rs1554893792  rs786204854  rs786204855  rs786202398  rs121909236  rs398123316  rs398123317  rs121909226  rs121909238  rs786204927  rs587782343  rs57374291  rs121909230  rs139767111  rs121909237  rs121909222  rs786204931  rs121909223  rs121909223  rs121909218  rs786204929  rs121909224  rs121909229  rs121909229  rs397514560  rs121909241  rs587782360  rs786204859  rs1060500126  rs587782603  rs786204863  rs397514559  rs121909221  rs121913293  rs121913294  rs121913294  rs587782316  rs121909234  rs905615413  rs121909235  rs121909240  rs587782350  rs121909239  rs562015640  rs35600253  rs1554825652  rs398123314 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959, ECO:0000269|PubMed:9187108}. Nucleus {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus, PML body {ECO:0000269|PubMed:18716620}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:O54857}. Postsynaptic density {ECO:0000250|UniProtKB:O54857}. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). Associares with the postsynaptic density in response to NMDAR activation (By similarity). {ECO:0000250|UniProtKB:O54857, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982}.;
[Isoform alpha]: Secreted {ECO:0000269|PubMed:23744781, ECO:0000269|PubMed:24768297}. Note=May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif. {ECO:0000269|PubMed:23744781, ECO:0000269|PubMed:24768297}.
Mouse PG classificationNA
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