| Gene Information | |
|---|---|
| Gene Name | RNF167 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000108523 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H6Y7 |
| Gene Card | RNF167 |
| Uniprot ID | Q9H6Y7 |
| Pfam | PF02225; PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.658740131) |
| Ortholog in Animals | Alpaca_ RNF167 ( ortholog_one2one ) GuineaPig_ RNF167 ( ortholog_one2one ) Macaque_ RNF167 ( ortholog_one2one ) Mouse_ Rnf167 ( ortholog_one2one ) Pig_ RNF167 ( ortholog_one2one ) Rat_ Rnf167 ( ortholog_one2one ) Rabbit_ RNF167 ( ortholog_one2one ) |
| Ohnologs | RNF13 |
| Paralogs | RNF133, RNF149, ZNRF4, RNF130, RNF150, RNF215, RNF128, RNF13, RNF148 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:23129617). Strongly expressed in the kidney, pancreas, testis and liver (at protein level) (PubMed:16314844, PubMed:23129617). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1127356 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:35114100}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:24387786}; Single-pass type I membrane protein {ECO:0000255}. Endomembrane system {ECO:0000269|PubMed:16314844}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23129617}; Single-pass type I membrane protein {ECO:0000255}. Note=Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane (PubMed:16314844, PubMed:23129617). A subpopulation localizes to the cell membrane of neurons (PubMed:23129617). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617}.; [Isoform 1]: Lysosome membrane {ECO:0000269|PubMed:32409562}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:32409562}. |
| Mouse PG classification | NA |
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