| Gene Information | |
|---|---|
| Gene Name | ITM2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 266 |
| Protein Names | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000136156 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y287 |
| Gene Card | ITM2B |
| Uniprot ID | Q9Y287 |
| Pfam | PF04089 |
| In ASD | no |
| Allosteric Prediction | no (-0.504009428) |
| Ortholog in Animals | Alpaca_ ITM2B ( ortholog_one2one ) Dog_ ITM2B ( ortholog_one2one ) GuineaPig_ ITM2B ( ortholog_one2one ) Macaque_ ITM2B ( ortholog_one2one ) Mouse_ Itm2b ( ortholog_one2one ) Pig_ ITM2B ( ortholog_one2one ) Rat_ Itm2b ( ortholog_one2one ) Rabbit_ ITM2B ( ortholog_one2one ) |
| Ohnologs | ITM2A, ITM2C |
| Paralogs | ITM2A, ITM2C |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expressed in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11556905 rs606231283 |
| Subcellular location [CC] | [Integral membrane protein 2B]: Golgi apparatus membrane {ECO:0000269|PubMed:14656991, ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Note=Immature BRI2 (imBRI2) is cleaved by furin in the Golgi into mBRI2 and a Bri23 peptide. mBRI2 is transported to the plasma membrane and Bri23 peptide is secreted.; [BRI2, membrane form]: Cell membrane {ECO:0000269|PubMed:18440095, ECO:0000269|PubMed:19748705, ECO:0000269|PubMed:21752865}; Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Endosome membrane {ECO:0000269|PubMed:19748705}; Single-pass type II membrane protein {ECO:0000269|PubMed:10526337}. Note=Mature BRI2 (mBRI2) needs to be transported from the endoplasmic reticulum compartment to the cell membrane in order to be able to inhibit APP processing. {ECO:0000269|PubMed:19748705}.; [Bri23 peptide]: Secreted {ECO:0000269|PubMed:10526337, ECO:0000269|PubMed:14656991, ECO:0000269|PubMed:18524908}. Note=Detected in the cerebral spinal fluid (CSF). {ECO:0000269|PubMed:18524908}.; [BRI2C, soluble form]: Secreted {ECO:0000269|PubMed:17965014}. |
| Mouse PG classification | LPG |
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