| Gene Information | |
|---|---|
| Gene Name | NEIL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) |
| Target Name | endonuclease 8-like 1 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000140398 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96FI4 |
| Gene Card | NEIL1 |
| Uniprot ID | Q96FI4 |
| Pfam | PF01149; PF09292 |
| In ASD | no |
| Allosteric Prediction | no (-0.367666248) |
| Ortholog in Animals | Alpaca_ NEIL1 ( ortholog_one2one ) Dog_ NEIL1 ( ortholog_one2one ) GuineaPig_ NEIL1 ( ortholog_one2one ) Macaque_ NEIL1 ( ortholog_one2one ) Mouse_ Neil1 ( ortholog_one2one ) Pig_ NEIL1 ( ortholog_one2one ) Rat_ Neil1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NEIL2, NEIL3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11904416}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1TDH (X-ray 2.10A ) 4NRV (X-ray 2.60A ) 5ITQ (X-ray 1.48A ) 5ITR (X-ray 2.46A ) 5ITT (X-ray 2.53A ) 5ITU (X-ray 2.41A ) 5ITX (X-ray 2.65A ) 5ITY (X-ray 2.48A ) 6LWA (X-ray 2.76A ) 6LWB (X-ray 2.55A ) 6LWC (X-ray 2.91A ) 6LWD (X-ray 2.41A ) 6LWF (X-ray 2.79A ) 6LWG (X-ray 2.53A ) 6LWH (X-ray 2.78A ) 6LWI (X-ray 2.72A ) 6LWJ (X-ray 2.83A ) 6LWK (X-ray 2.88A ) 6LWL (X-ray 2.55A ) 6LWM (X-ray 2.67A ) 6LWN (X-ray 2.74A ) 6LWO (X-ray 2.51A ) 6LWP (X-ray 2.64A ) 6LWQ (X-ray 2.89A ) 6LWR (X-ray 2.90A ) |
| DBSNP | rs5745905 rs5745906 rs5745907 rs769880000 rs749636951 rs7183491 rs5745926 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556049}. Nucleus {ECO:0000269|PubMed:17556049}. Chromosome {ECO:0000269|PubMed:17556049}. Note=During mitosis, associates with centrosomes and condensed chromatin. |
| Mouse PG classification | NA |
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