| Gene Information | |
|---|---|
| Gene Name | RNF138 |
| Organism | Homo sapiens (Human) |
| Gene Length | 245 |
| Protein Names | E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000134758 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8WVD3 |
| Gene Card | RNF138 |
| Uniprot ID | Q8WVD3 |
| Pfam | PF05605; PF18574 |
| In ASD | no |
| Allosteric Prediction | no (-0.652152578) |
| Ortholog in Animals | Alpaca_ RNF138 ( ortholog_one2one ) Dog_ RNF138 ( ortholog_one2one ) GuineaPig_ RNF138 ( ortholog_one2one ) Macaque_ RNF138 ( ortholog_one2one ) Mouse_ Rnf138 ( ortholog_one2one ) Pig_ RNF138 ( ortholog_one2one ) Rat_ AABR07031480.1 ( ortholog_one2one ) Rabbit_ RNF138 ( ortholog_one2one ) |
| Ohnologs | RNF114 |
| Paralogs | RNF125, RNF114, RNF166, RNF180 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7229690 |
| Subcellular location [CC] | Chromosome {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. Note=Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. |
| Mouse PG classification | NA |
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