| Gene Information | |
|---|---|
| Gene Name | HSD17B11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 300 |
| Protein Names | Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2) |
| Target Name | estradiol 17-beta-dehydrogenase 11 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000198189 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q8NBQ5 |
| Gene Card | HSD17B11 |
| Uniprot ID | Q8NBQ5 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | no (-0.159636888) |
| Ortholog in Animals | Alpaca_ HSD17B11 ( ortholog_one2one ) Dog_ HSD17B13 ( ortholog_one2one ) GuineaPig_ HSD17B11 ( ortholog_one2one ) Macaque_ HSD17B11 ( ortholog_one2one ) Mouse_ Hsd17b11 ( ortholog_one2one ) Pig_ HSD17B11 ( ortholog_one2one ) Rat_ Hsd17b11 ( ortholog_one2one ) Rabbit_ HSD17B11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, BDH1, WWOX, HSD17B2, RDH5, DHRS3, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6 |
| Tissue | NA |
| Tissue Specificity | Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart. {ECO:0000269|PubMed:10800688, ECO:0000269|PubMed:11165019, ECO:0000269|PubMed:12697717, ECO:0000269|PubMed:9888557}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1YB1 (X-ray 1.95A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9EQ06}. Lipid droplet {ECO:0000250|UniProtKB:Q9EQ06}. Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. {ECO:0000250|UniProtKB:Q9EQ06}. |
| Mouse PG classification | NA |
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