| Gene Information | |
|---|---|
| Gene Name | RNF13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 381 |
| Protein Names | E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000082996 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43567 |
| Gene Card | RNF13 |
| Uniprot ID | O43567 |
| Pfam | PF02225; PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-1.340023016) |
| Ortholog in Animals | Alpaca_ RNF13 ( ortholog_one2one ) Dog_ RNF13 ( ortholog_one2one ) GuineaPig_ RNF13 ( ortholog_one2one ) Macaque_ RNF13 ( ortholog_one2one ) Mouse_ Rnf13 ( ortholog_one2one ) Pig_ RNF13 ( ortholog_one2one ) Rat_ Rnf13 ( ortholog_one2one ) Rabbit_ RNF13 ( ortholog_one2one ) |
| Ohnologs | RNF167 |
| Paralogs | RNF133, RNF149, ZNRF4, RNF130, RNF150, RNF215, RNF128, RNF167, RNF148 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level). {ECO:0000269|PubMed:18794910}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5ZBU (X-ray 3.20A ) 5ZC4 (X-ray 1.91A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:18794910, ECO:0000269|PubMed:23378536, ECO:0000269|PubMed:24387786}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000305|PubMed:24387786}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250|UniProtKB:O54965}. |
| Mouse PG classification | NA |
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