| Gene Information | |
|---|---|
| Gene Name | RNF115 |
| Organism | Homo sapiens (Human) |
| Gene Length | 304 |
| Protein Names | E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000265491 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y4L5 |
| Gene Card | RNF115 |
| Uniprot ID | Q9Y4L5 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.822123146) |
| Ortholog in Animals | Alpaca_ RNF115 ( ortholog_one2one ) GuineaPig_ RNF115 ( ortholog_one2one ) Macaque_ RNF115 ( ortholog_one2one ) Mouse_ Rnf115 ( ortholog_one2one ) Pig_ RNF115 ( ortholog_one2one ) Rat_ Rnf115 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF126, RNF181 |
| Tissue | NA |
| Tissue Specificity | Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells. {ECO:0000269|PubMed:16288031}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11577731 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D0C1}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9D0C1}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |