| Gene Information | |
|---|---|
| Gene Name | RNF113A |
| Organism | Homo sapiens (Human) |
| Gene Length | 343 |
| Protein Names | E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000125352 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15541 |
| Gene Card | RNF113A |
| Uniprot ID | O15541 |
| Pfam | PF00642 |
| In ASD | no |
| Allosteric Prediction | no (-1.135576321) |
| Ortholog in Animals | Alpaca_ RNF113A ( ortholog_one2one ) Dog_ RNF113A ( ortholog_one2one ) GuineaPig_ RNF113A ( ortholog_one2one ) Macaque_ RNF113A ( ortholog_one2one ) Mouse_ Rnf113a2 ( ortholog_one2one ) Pig_ RNF113A ( ortholog_one2one ) Rat_ Rnf113a2 ( ortholog_one2one ) Rabbit_ RNF113A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF113B |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9224902}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.15589(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5Z56 (EM 5.10A ) 5Z58 (EM 4.90A ) 6FF4 (EM 16.00A ) 6FF7 (EM 4.50A ) 7DVQ (EM 2.89A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316}. Nucleus speckle {ECO:0000269|PubMed:29144457}. Note=Colocalizes with ASCC2 in nuclear foci after DNA damage by alkylating agents. In the absence of DNA damage, colocalizes with the spliceosome components SNRNP200/BRR2 and PRPF8 in nuclear speckles. {ECO:0000269|PubMed:29144457}. |
| Mouse PG classification | NA |
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